学術データベース

Sn-2パルミチン酸強化脂質は、老化促進マウスの早期老化表現型を軽減する
Sn-2 palmitate-enriched structured lipids attenuate early aging phenotypes in senescence-accelerated mice.

著者名

阪上　浩 (Hiroshi Sakaue)

共著者名

Rie Tsutsumi, Sae Tanaka, Yui Funatsu, Yoshihiro Meta, Yuna Izumi-Mishima, Kazuhiro Nomura, Hiroshi Sakaue

出版社／掲載誌名

J Nutr Biochem.

出版日

2026/8

キーワード

anti-aging; mitochondria; senescence-accelerated mouse; sn-2 palmitate

概要

Aging is characterized by cognitive decline and metabolic abnormalities. Lipids with palmitic acid at the β-position (sn-2 palmitic acid), which are abundant in breast milk fat, regulate inflammation and lipid metabolism, but their effect on aging was unclear. In this study, aging-accelerated mice (SAMP8) were administered Sn-2 palmitate-enriched lipids for 8 weeks. As a result, cognitive function improved, and hippocampal aging markers (p16, p21) and inflammatory cytokines (IL-6, TNF-α) decreased. Furthermore, the NAD⁺/NADH ratio and Sirt1/3 activity increased, and mitochondrial biosynthesis-related factors (PGC-1α, NRF1, TFAM) increased. This suggests that Sn-2 palmitate-enriched lipids may mitigate aging-related cognitive and physiological declines through NAD⁺ metabolism and mitochondrial function.