学術データベース

インスリンは、ラットにおけるSTZ誘発糖尿病の初期段階において、速筋線維の筋肉量を維持する
Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats

著者名

阪上　浩 (Hiroshi Sakaue )

共著者名

Yuki Yamasaki, Kazuhiro Nomura, Yuka Matsumoto, Kana Fukuda-Takeji, Yumiko Miyatake, Naoya Suemasa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Masashi Kuroda, Nagakatsu Harada, Yasuo M Tsutsumi, Tadahiro Kitamura, Rie Tsutsumi, Yutaka Nakaya , Hiroshi Sakaue

出版社／掲載誌名

Biochem Biophys Rep

巻号

46

頁

102627

出版日

2026/5

キーワード

Insulin; Skeletal muscle atrophy; Type 1 diabetes mellitus; Voluntary exercise

概要

This study investigated the effects of voluntary exercise on early-stage muscle atrophy in streptozotocin (STZ)-induced type 1 diabetic rats. The results demonstrated that the primary cause of muscle atrophy was insulin deficiency rather than reduced physical activity, and that voluntary exercise alone was insufficient to prevent muscle loss. In contrast, insulin treatment suppressed the reduction in muscle mass, while leucine supplementation partially attenuated muscle atrophy. These findings suggest that leucine supplementation may represent a promising therapeutic strategy for preventing muscle loss under insulin-deficient conditions.