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DNA methyltransferase inhibition by 5-azacytidine promotes thermogenic programming in beige adipocytes
著者名
(
Hiroshi Sakaue
)
共著者名
Masashi Kuroda/Kazuhiro Nomura/Rin Chamoto/Yuna Izumi-Mishima/Sonoko Yasui-Yamada/Yasuo M Tsutsumi/Rie Tsutsumi
出版社／掲載誌名
Biochem Biophys Res Commun
巻号
774
頁
152094
出版日
2025/5
キーワード
5-Azacytidine/Beige adipocyte/DNA methylation/Thermogenic gene expression
概要
Beige adipocytes regulate energy metabolism via thermogenesis, influenced by DNA methylation. This study examined how DNA demethylation using 5-azacytidine (5-AzaC) affects beige adipocyte function. While 5-AzaC did not alter differentiation, it enhanced thermogenic gene expression (e.g., Ucp1, Cox7a1), mitochondrial activity, and fatty acid uptake. These findings suggest a role for DNA demethylation in modulating beige adipocyte function, with potential relevance to obesity and type 2 diabetes.
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