学術データベース
学術データ詳細

Inhibition of octapeptide N-Myristoylation by acyl amino acid and acyl alkanolamines.
著者名
田渕　正樹 (Tabuchi Masaki)
共著者名
Okamoto H, Furutani T, Azuma M, Ooshima H, Otake T, Kawahara T, Kato J.
出版社／掲載誌名
J. Enzyme Inhib.
巻号
12
頁
27-36
出版日
1997/12
概要
Several acyl amino acids and acyl alkanolamines were prepared and screened for their inhibition of octapeptide N-myristoylation and HIV-1 replication in MT-4 cells. Of the 62 acyl derivatives tested, N-myristoyl-O-caproyl-L-serine, N-myristoyl-O-caproyl-D-serine and N-decanoyl-O-myristoyl-L-serine were found to be uncompetitive inhibitors of N-myristoylation, but did not prevent HIV-induced cytopathicity in MT-4 cells. However, other acyl derivatives such as N-3-hydroxymyristoyl ethanolamine, N-3-hydroxymyristoyl-D-serine and N-myristoyl-L-cysteine, which did not inhibit N-myristoylation, suppressed the cytopathicity in the infected cells. The acyl derivatives described here may serve as lead compounds for antiviral agents.
閉じる
Top