学術データベース

化学療法による悪心および栄養状態に対するショウガ含有の無色・無脂肪経口栄養補助食品の予備的ランダム化比較試験
A preliminary randomized controlled trial of a ginger-containing, clear, fat-free oral nutritional Supplement for chemotherapy-induced nausea and nutritional outcomes

著者名

阪上　浩 (Hiroshi Sakaue)

共著者名

Rie Tsutsumi, Soshi Narasaki, Yousuke T. Horikawa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Kazuhiro Nomura, Yasuo M. Tsutsumi

出版社／掲載誌名

Clinical Nutrition Open Science

巻号

66

頁

100617

出版日

2026/4

キーワード

Chemotherapy-induced nausea and vomiting (CINV), Oral nutrition supplement (ONS), Fat free, Ginger extract, Cancer

概要

Chemotherapy-induced nausea and vomiting (CINV) affects nearly 40% of patients undergoing cancer treatment and remains a major barrier to treatment adherence and adequate nutritional intake. In this prospective randomized study, we evaluated whether an oral nutritional supplement (ONS) containing ginger extract could alleviate CINV. Seventy-five patients were randomized to a control group without ONS, a conventional ONS group, or a fat-free ONS containing ginger extract. After the second cycle of chemotherapy, patients receiving the ginger-containing ONS exhibited markedly lower nausea scores compared with both the control and conventional ONS groups. This improvement was accompanied by a significant reduction in serum substance P levels, a key mediator of emesis. Notably, the ginger ONS group also showed increased energy and protein intake, along with improvements in body weight, lean body mass, and quality of life. These findings suggest that a specifically formulated ginger-containing ONS may represent a promising supportive strategy to mitigate CINV while preserving nutritional status during chemotherapy.